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Ivermectin


Bernard

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Ivermectin in COVID-19

These pages contain the scientific rationale that justifies the use of ivermectin in COVID-19.

We regard ivermectin as a core medication in the prevention and treatment of COVID-19. For comprehensive information on ivermectin please refer to our Review of the Emerging Evidence Supporting the Use of Ivermectin in the Prophylaxis and Treatment of COVID-19 and the included references.

For questions about the safety of this medicine, you can read the expert review of over 350 articles on the medical safety profile of ivermectin that was conducted by a toxicologist for Medincell, which reported that “No safety concern was anticipated that would prevent health authorities from assessing the use of Ivermectin against COVID-19.” The review is available at www.medincell.com/ivermectin

A more recent paper, Meta-analysis of Randomized Trials of Ivermectin to treat SARS-CoV-2 Infection was accepted for publication July 6, 2021, by Oxford University Press on behalf of the Infectious Diseases Society of America. This study was done by Dr. Andrew Hill and the team that researched ivermectin’s efficacy in COVID-19 treatment for the WHO. The data is overwhelmingly positive and was discussed in detail by Dr. Pierre Kory on the FLCCC’s July 7, 2021, Weekly Update.

Another recent paper, Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines was published online June 17, 2021, by the American Journal of Therapeutics. It concludes, “Moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin. Using ivermectin early in the clinical course may reduce numbers progressing to severe disease. The apparent safety and low cost suggest that ivermectin is likely to have a significant impact on the SARS-CoV-2 pandemic globally.”

For PATIENTS AND RELATIVES, please review our GUIDE FOR YOU. It tells how to find physicians who prescribe ivermectin as well as provides information to share with your primary care physician in the event that he or she is not aware of the current evidence detailing how safe and effective ivermectin is in preventing and treating all stages of COVID-19 and all variants of the SARS-CoV-2 virus.

 

Ivermectin is a well-known, FDA-approved anti-parasite drug that has been used successfully for more than four decades to treat onchocerciasis “river blindness” and other parasitic diseases. It is one of the safest drugs known. It is on the WHO’s list of essential medicines, has been given 3.7 billion times around the globe, and has won the Nobel prize for its global and historic impacts in eradicating endemic parasitic infections in many parts of the world. Our medical discovery of a rapidly growing published medical evidence base, demonstrating ivermectin’s unique and highly potent ability to inhibit SARS-CoV-2 replication and to suppress inflammation, prompted our team to use ivermectin for prevention and treatment in all stages of COVID-19. Ivermectin is not yet FDA-approved for the treatment of COVID-19, but on Jan 14, 2021, the NIH changed their recommendation for the use of ivermectin in COVID-19 from “against” to “neutral”. (see our  press release).

In March 2020 we created our life-saving  MATH+ Hospital Treatment Protocol for COVID-19, which is intended for hospitalized patients. In October 2020 we developed the  I-MASK+ Prophylaxis & Early Outpatient Treatment Protocol for COVID-19, which is designed for use as a prophylaxis and in early outpatient treatment, for those who test positive for COVID-19. The protocols complement each other, and both are physiologic-based combination treatment regimens developed by leaders in critical care medicine. All the component medicines are FDA-approved, inexpensive, readily available and have been used for decades with well-established safety profiles. Both protocols are  available in several languages.

More recent studies and clinical trials on ivermectin

 

August 26, 2021 | Cureus
“Ivermectin as a SARS-CoV-2 Pre-Exposure Preventive in Healthcare Workers: a Propensity Score-Matched Retrospective Cohort Study”
a study from doctors who continued to use ivermectin to subdue COVID-19 with great success in the Dominican Republic.
 IVM as a Covid Pre-Exposure Preventive.

June 15, 2021 | J Antibiot (Tokyo)
“The mechanisms of action” of Ivermectin against SARS-CoV-2: An evidence-based clinical review article.” reports overwhelmingly positive data for ivermectin’s use in the pandemic.
“100% of 36 early treatment and prophylaxis studies report positive effects… using the most serious outcome reported 79% and 85% improvement for early treatment and prophylaxis respectively…Statistically significant improvements were seen for mortality, ventilation, hospitalization, cases, and viral clearance…100% of the 17 Randomized Controlled Trials (RCTs) for early treatment and prophylaxis report positive effects, with an estimated improvement of 73% and 83% respectively, and 93% of all 28 RCTs.)… The consistency of positive results across a wide variety of cases has been remarkable. It is extremely unlikely that the observed results could have occurred by chance.”

Favorable outcome on viral load and culture viability using Ivermectin in early treatment of non-hospitalized patients with mild COVID-19 – A double-blind, randomized placebo-controlled trial can be found at the following link: https://www.medrxiv.org/content/10.1101/2021.05.31.21258081v1

For an up-to-date overview of all published studies on ivermectin in the treatment and prevention of COVID-19 we recommend visiting  c19ivermectin.com; in addition, a meta-analysis of all studies can be found at  ivmmeta.com (constantly updated).

A majority of the studies (until January 12, 2021) were included in our comprehensive  Review of the Emerging Evidence Supporting the Use of Ivermectin in the Prophylaxis and Treatment of COVID-19, and a brief summary of the studies at that time can be found in the accompanying  One-page summary of the scientific review on ivermectin.

 

Summary of studies on the use of ivermectin in COVID-19:

isummary.png

 

ivmworld.svg

 

COVID19CRITICALCARE.COM

The MATH+ Hospital Treatment Protocol for Covid-19 is a physiologic-based combination treatment regimen created by leaders in critical care medicine.

 

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Why all the fuss about Ivermectin?

 

 

First hydroxychloroquine, now ivermectin, is the hated deadly drug de jour, castigated by the medical establishment and regulatory authorities. Both drugs have been around for a long time as FDA-approved prescription medications. Yet now we are told they are as deadly as arsenic.

As a physician, I am certainly aware of ivermectin but don’t recall ever writing a prescription for it in my 30+ years’ medical career. Ivermectin is an anthelmintic, meaning it cures parasitic infections. In my world of ophthalmology, it is used on occasion for rare parasitic or worm infections in the eye.

Ivermectin was FDA approved in 1998 under the brand name Stromectol, produced by pharmaceutical giant Merck, approved for several parasitic infections. The product label described it as having a “unique mode of action,” which “leads to an increase in the permeability of the cell membrane to chloride ions.” This suggests that ivermectin acts as an ionophore, making cell membranes permeable to ions that enter the cell for therapeutic effect.

Ivermectin is one of several ionophores, others including hydroxychloroquine, quercetin, and resveratrol, the latter two available over the counter. These ionophores simply open a cellular door, allowing zinc to enter the cell, where it then interferes with viral replication, providing potential therapeutic benefit in viral and other infections.

This scientific paper reviews and references other studies demonstrating antibacterial, antiviral, and anticancer properties of ivermectin. This explains the interest in this drug as having potential use in treating COVID.

AP21139578852594.jpg

 

https://www.americanthinker.com/articles/2021/09/why_all_the_fuss_about_ivermectin.html

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COVID-19: Why Does Ivermectin Continue To Be Popular?

2021-04-20T051155Z_1_LYNXMPEH3J056_RTROPTP_4_HEALTH-CORONAVIRUS-BOLIVIA-DRUG.jpg

 

SCIENCE.THEWIRE.IN

Doctors have said that they are pressured to prescribe the drug to COVID-19 patients even though they are aware that it has no beneficial effect.

 

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India has charged WHO scientist Dr. Soumya Swaminathan with mass murder.

India has charged WHO scientist Dr. Soumya Swaminathan with mass murder.

 

The Indian Bar Association, a private voluntary organization of lawyers, has no jurisdiction to charge the scientist with murder.

Articles claiming that India has charged World Health Organization (WHO) scientist, Dr. Soumya Swaminathan, with mass murder are doing the rounds on social media.

WWW.LOGICALLY.AI

The Indian Bar Association, a private voluntary organization of lawyers, has no jurisdiction to charge the scientist with murder.

 

Indian Bar Association serves legal notice to chief WHO scientist for misinformation on ivermectin


Dr. Soumya Swaminathan is accused of ‘[r]unning a disinformation campaign against Ivermectin by deliberate suppression of effectiveness of drug Ivermectin as prophylaxis and for treatment of COVID-19.’
 
 
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The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer

Abstract

Infection by RNA viruses such as human immunodeficiency virus (HIV)-1, influenza, and dengue virus (DENV) represent a major burden for human health worldwide. Although RNA viruses replicate in the infected host cell cytoplasm, the nucleus is central to key stages of the infectious cycle of HIV-1 and influenza, and an important target of DENV nonstructural protein 5 (NS5) in limiting the host antiviral response. We previously identified the small molecule ivermectin as an inhibitor of HIV-1 integrase nuclear entry, subsequently showing ivermectin could inhibit DENV NS5 nuclear import, as well as limit infection by viruses such as HIV-1 and DENV. We show here that ivermectin's broad spectrum antiviral activity relates to its ability to target the host importin (IMP) α/β1 nuclear transport proteins responsible for nuclear entry of cargoes such as integrase and NS5. We establish for the first time that ivermectin can dissociate the preformed IMPα/β1 heterodimer, as well as prevent its formation, through binding to the IMPα armadillo (ARM) repeat domain to impact IMPα thermal stability and α-helicity. We show that ivermectin inhibits NS5-IMPα interaction in a cell context using quantitative bimolecular fluorescence complementation. Finally, we show for the first time that ivermectin can limit infection by the DENV-related West Nile virus at low (μM) concentrations. Since it is FDA approved for parasitic indications, ivermectin merits closer consideration as a broad spectrum antiviral of interest.

 

PUBMED.NCBI.NLM.NIH.GOV

Infection by RNA viruses such as human immunodeficiency virus (HIV)-1, influenza, and dengue virus (DENV) represent a major burden for human health worldwide. Although RNA viruses...

 

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Japanese Medical Association Now Endorses Ivermectin for Covid-19

               ivmct.jpg

 

THEHEALTHEDGE.COM

The chairman of the Tokyo Medical Association, Haruo Ozaki, held a press conference Feb. 9, 2021 announcing that the anti-parasite medicine Ivermectin seems to be effective at stopping COVID-19...

 

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пре 1 сат, cloudking рече

 

Zato sto je glupe ljude moguce ubediti da piju spiritus zbog zdravlja a kamoli da konjski lek leci koronu :))

Zasto je glupe ljude moguce ubediti da lek koji se koristi i za ljude i za zivotinje koriste samo zivotinje?  :))

 

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@cloudking obrazuj se sam tupane tupavi... a ne da ti Ivkovic ispira mozak...

Evo ti ukratko sta nauka kaze, a Ivkovic nece.. lek je pokazao da u nekim dozama ima pozitivnog efekta na covid, ali su te doze toksicne po ljude pa se ne preporucuje bas. Lik nije konjski nego je univerzalan (kao i brufen naprimer) koriste ga i zivotinje i ljudi. Sve ti to pise u naucnim studijama, a ti se dozovi malo pameti pa sam citaj studije, a ne blogove... i misljenja polupropalih radiologa.. dokazanih lazova.. 

SCHOLAR.GOOGLE.COM
WWW.NATURE.COM

The Journal of Antibiotics - <ArticleTitle Language="En" xml:lang="en">Ivermectin: a systematic review from antiviral effects to COVID-19...

 

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пре 31 минута, haveaniceday рече

Zasto je glupe ljude moguce ubediti da lek koji se koristi i za ljude i za zivotinje koriste samo zivotinje?  :))

 

Ne, ne. Gutaj ivermektin :) zbunio sam se nesto. Super je lek. Kazu na jucubu da leci koronu a znas sta kazu za jucub...

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пре 3 минута, cloudking рече

Kazu na jucubu da leci koronu a znas sta kazu za jucub...

Bukvalno sam ti ostavio linkove za pet naucnih radova.... ni jedan nije jutjub link.
Je l vi glumci razvijete neku patologiju pa lazete toliko ili? 
 

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пре 25 минута, haveaniceday рече

. i misljenja polupropalih radiologa

Hahahah kolko odlepio covek! Kakve pa ja sad imam veze sa Ivkovicem? :))

Nit ga pominjem nit sam ga pominjao...

Dakle, nema toga sto neces da izgovoris kroz to prdalo, a? :)

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Управо сада, haveaniceday рече

Gutas ono sto ti doktor prepise, a ne ono sto ti preporuci radiolog u svom blogu. 
Tako makar stvari trebaju da idu.. 

Kakav doktor? To sve placene budale da truju narod cipovima i otrovima... Videces za 60-70 godina kad umres... Bice posle, lepo mi je govorio klaud da ne slusam lekare, ee...

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